Synthesis and Characterization of Multifunctional Chitosan-MnFe2O4 Nanoparticles for Magnetic Hyperthermia and Drug Delivery
نویسندگان
چکیده
Multifunctional nanoparticles composed of MnFe₂O₄ were encapsulated in chitosan for investigation of system to combine magnetically-triggered drug delivery and localized hyperthermia for cancer treatment with the previously published capacity of MnFe₂O₄ to be used as an efficient MRI contrast agent for cancer diagnosis. This paper focuses on the synthesis and characterization of magnetic MnFe₂O₄ nanoparticles, their dispersion in water and their incorporation in chitosan, which serves as a drug carrier. The surface of the MnFe₂O₄ nanoparticles was modified with meso-2,3-di-mercaptosuccinic acid (DMSA) to develop stable aqueous dispersions. The nanoparticles were coated with chitosan, and the magnetic properties, heat generation and hydrodynamic size of chitosan-coated MnFe₂O₄ were evaluated for various linker concentrations and in a range of pH conditions.
منابع مشابه
FeMn2O4 nanoparticles coated dual responsive temperature and pH-responsive polymer as a magnetic nano-carrier for controlled delivery of letrozole anti-cancer
Objective(s): For cancer cells, an efficient and selective drug delivery vehicle can remarkably improve therapeutic approaches. This paper focuses on the synthesis and characterization of magnetic MnFe2O4 NPs and their incorporation in a dual temperature and pH-responsive polymer, which can serve as an efficient drug carrier. Materials and Methods: MnFe2O4 NPs were synthesized by chemical co-pr...
متن کاملGreen synthesis of Iron oxide nanoparticles using carum carvi L. and modified with chitosan in order to optimize the anti-cancer drug adsorption
Magnetic iron oxide nanoparticles have gained a lot of attention in drug delivery systems because they can control a drug pathway to deliver it to the specific site under a magnetic field which is related to their magnetic core and surface coating. Chitosan-coated FeNPs, have prominent antimicrobial and biological properties that make chitosan a promising biopolymer for drug delivery applicatio...
متن کاملGreen synthesis of Iron oxide nanoparticles using carum carvi L. and modified with chitosan in order to optimize the anti-cancer drug adsorption
Magnetic iron oxide nanoparticles have gained a lot of attention in drug delivery systems because they can control a drug pathway to deliver it to the specific site under a magnetic field which is related to their magnetic core and surface coating. Chitosan-coated FeNPs, have prominent antimicrobial and biological properties that make chitosan a promising biopolymer for drug delivery applicatio...
متن کاملAn Overview of Cobalt Ferrite Core-Shell Nanoparticles for Magnetic Hyperthermia Applications
Cobalt ferrite nanoparticles (CoFe2O4) are well known for some distinctive characteristics such as high magnetic permeability and coercive force, good saturation magnetization, excellent physical, and chemical stability, which make them so attractive for magnetic storage, magnetic resonance imaging (MRI), drug delivery, optical-magnetic equipment, radar absorbing materials...
متن کاملSynthesis and Characterization of Fe3O4 Magnetic Nanoparticles Coated with Carboxymethyl Chitosan Grafted Sodium Methacrylate
N-sodium acrylate-O-carboxymethyl chitosan [CMCH-g-PAA(Na)] bound Fe3O4 nanoparticles were developed as a novel magnetic nanoparticles with an ionic structure that can be potentially used in many fields. CMCH-g-PAA (Na) was obtained by grafting of sodium polyacrylate on O-carboxymethyl chitosan, which is an amphiphilic polyelectrolyte with the biocompatibility and biodegra...
متن کامل